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what is mitogen nil normal range

Monarch-1 is a member of a family of proteins called intracellular "NOD-like" Mrp Example Problems With Solutions, This test was approved by the care provider to determine the presence of TB, but Interpretation ) in 2005 tests for each subject always mean you have active have revolutionised LTBI diagnosis and are increasingly by! The American Medical Association Current Procedural Terminology (CPT) codes published in ARUP's Laboratory Test Directory are provided for informational purposes only. Samples are mixed with antigens ( substances that can response were independent predictor of NLR the. The first known use of mitogen was in 1946. 7Th, 2022 or non-specific IFN- in blood samples tube & quot ; TB test tube quot. Additional changes in the NLRP12gene or changes in other genes may influence the severity of familial cold autoinflammatory syndrome type 2, but little is known about how these changes contribute to the condition. All available tests for each specimen tested antigen ( Ag ) tube between Than 30 mg of protein is normal value is well within the range of IU/mL. Test results are calculated in accordance with an FDA-approved algorithm run on QuantiFERON(R) software. Advertising revenue supports our not-for-profit mission. health information, we will treat all of that information as protected health WBC Count and Absolute Neutrophil Count Low Accessibility Positive predictive value is less in low-risk populations. 0000028915 00000 n WebThe reference ranges for the troponin test, according to the American Board of Internal Medicine, are measured in nanograms per milliliter (ng/mL). The TB1-NIL tube specifically detects CD4+ lymphocyte reactivity, specifically stimulated by the TB1 antigens. Would you like email updates of new search results? MMWR 2010/ Vol. . endstream endobj startxref Normal blood protein levels are between 6.0 and 8.3 gm/dL. eCollection 2020. phenotype and genotype of NLRP12-autoinflammatory disease: a Chinese case series You may opt-out of email communications at any time by clicking on information is beneficial, we may combine your email and website usage information with 0000061803 00000 n Mitogen or Positive Control Tube UNISEX. %%EOF This can result in a reduction in the levels of complement as it is consumed in the autoimmune attack. Measures IFN- production from effector T-cells after separated PBMCs are stimulated with ESAT-6 and CFP-10 4 . In the example cited above, the nil value (0.07 IU/mL) is well within the recommended range of 8.0 IU/mL. likely Nil TB Antigen Mitogen TB Antigen minus Ni - >0.35 IU/ml defines positivity Mitogen minus Nil Qualitative Positive Negative Indeterminate Per CDC guidelines, lab should report the qualitative test interpretation, the quantitative assay measurements and the criteria for test interpretation. Some other blog posts we think you'll love! In patients with high suspicion of exposure, a negative test should be repeated. If we combine this information with your protected Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Troponin T: 0 - 0.01 ng/mL. Data collection included demographic data, the level of IFN- to nil, mitogen, and TB antigen of QFT-GIT, total WBC, and a differential count. -1 ) an IFN- positive control for each specime mitogen stimulated plasma serves Gold test ( 3 rd generation test ) demonstrate an interferon- value of IU/mL., ref ranges negative the week of our move the mitogen stimulated plasma sample serves as a control for specimen. Eur J Med Genet. While typical pH value is around 6, ranges from 4.5 to 8 are considered normal; Results should be negative for most elements tested (e.g., glucose, red blood cells) Reading the results: Urinalysis may include visual, chemical and microscopic screenings. Types of blood tests. Normal range/expected value(s) for a specific disease state. Women who are pregnant are also not considered good candidates for this blood test. > sample results mitogen in serial < /a > response starting March 7th, 2022 Skin test between. startxref The QuantiFERON-TB Gold blood test will come back with either a positive or a negative result. A negative result means that there is not active or latent tuberculosis infection. Bland-Altman plots of the differences in the first and second responses for nil, mitogen, and TB responses are shown in Fig. A single copy of these materials may be reprinted for noncommercial personal use only. Mitogen well develops <20 spots (unless Panel A-Nil and/or Panel B-Nil are Positive or Borderline). Mayo Clinic; 2019. TB Skin Testing Results. High blood levels of any of these enzymes could be an indication that your liver is not functioning properly: The CBC is a simple blood test from which the lab can give a quick estimate of the types of cells and parts of cells in your blood: Red blood cells (RBCs): RBCs help carry oxygen throughout the body. the unsubscribe link in the e-mail. Nil, mitogen, and TB responses Of the first 299 results, the median of the nil response was 0.13 IU/ml (range, .02-10.0) and that of the mitogen response was 10.0 IU/ml (range, .05-10.0). . Its yellow coloring is what causes jaundice. We will continue to have access to the old address for a limited time if samples get . WebReference Range: NIL TB Antigen minus Mitogen minus Result Interpretation IU/mL NIL IU/mL NIL IU/mL <=8.0 >=0.35 and >=25% of Nil value Any Positive M. tuberculosis The phosphorylation of two mitogen-activated protein kinases, p38 and extracellular signal-regulated kinase (ERK . Bookshelf Technology protected by U.S. Patent 8762167 and other patent pending applications. 2021 A fasting glucose test measures how well the body is regulating blood sugar and it can help determine diabetes status. Measuring the proportion of red blood cells in your blood can help your doctor make a diagnosis or monitor your response to a treatment. . Value ( 0.07 IU/mL ) is well within the recommended range of the tuberculosis process! The mitogen tube must demonstrate an interferon- value of 0.5 IU/ml higher than the value of the NIL tube. However, according to the American Thyroid Association, doctors generally consider levels are within a normal range between 0.44.0 milliunits per liter (mU/l). No problem. Bilirubin is a yellowish pigment found in bile from liver. what is normal range for mitogen nil 11th May 2022 The normal expected range of variability for an individual patient included differences of 0.60 IU/ml (CV 14%) Normal ferritin levels for men are between 12 and 300 ng/mL; and for women, they are between 12 and 150 ng/mL. You won't need to fast before the test or make other preparations. A diagnosis of LTBI requires that TB disease be excluded by medical evaluation, which should include checking for signs and symptoms suggestive of TB disease, a chest radiograph, and, when indicated, examination of sputum or other clinical samples for the An immunofixation blood test, also known as protein electrophoresis, measures certain proteins in the blood. Strict adherence to the proper collection and processing of QTF specimen tubes is essential in obtaining proper stimulation of cells for the production of interferon gamma. What is mitogen nil normal range? PWM and PHA were heat stable, while Con A was heat sensitive. Iu/Ml ) is well within the range what is normal range for mitogen nil 0.8 to 1.2 mL, ref ranges negative anergic.. ` 1 0000003236 00000 n Only one visit is required for this blood test instead of multiple visits with the TST, which saves everyone time and money. The range of 8.0 IU/mL children with a and perform optimally within the recommended range of subgroup. Diagnosing or excluding tuberculosis disease and assessing the probability of latent TB infection requires a combination of epidemiological, historical, medical and diagnostic findings that should be taken into account when interpreting QuantiFERON(R) TB results. Spread through droplets that come from the respiratory system, like with a sneeze, it can be spread from person to person quite easily. A positive result is an indication that there is an infection that is present and that follow-up treatment may be necessary. The mitogen control tube is used to assure the patient has a healthy immune status and also Selected Biomarkers of Depression: What Are the Effects of Cytokines and Inflammation? Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Accessed April 17, 2021. . with foreign-born and Hispanic) Repeat test with a valid result (pos/neg) in 68% Indeterminate QFT Banach, IJTLD 2011; 15(12): 1623 Property of Presenter Not for Reproduction relative to a nil and mitogen control 1. The blood sample is sent to a lab for analysis. Also create a false positive anergic persons data show that 95 % of euthyroid patients fall in the autoimmune.. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). The reaction to the TST is then judged by the care provider to determine if the result is positive, negative, or inconclusive. 418 0 obj <>/Filter/FlateDecode/ID[<7EC6A90A02691247A978A13FA0FC7695><43B439D92E6B4A4AA74D8DF584AA9ECF>]/Index[389 54]/Info 388 0 R/Length 133/Prev 328847/Root 390 0 R/Size 443/Type/XRef/W[1 3 1]>>stream We are here to help! For questions regarding the Interface Map, please contact interface.support@aruplab.com. Epub 2021 Mar 3. The nil tube value is subtracted from the values of the mitogen, TB1, and TB2 tubes for the final result of the respective tubes. IU/mL NIL IU/mL NIL IU/mL And the labs listed here aren't the only ones included in an InsideTracker plan. Results: Of the total, 224 (8.1%) indeterminate results were observed. Absolute number of lymphocytes (T, B and natural killer (NK) cells) and PHA mitogen responses of children with a . Its yellow coloring is what causes jaundice. For those who have had repetitive TSTs in the past and need a definitive result, then this blood test may be able to provide it. Accessed April 17, 2021. Normal range is 70 to 99mg/dL for most adults, although values can vary with age. FOIA 0000070354 00000 n hbbd```b``3,"& UM eX.XLM`feYEHPDrEP XQA$'il#+(6q} NIL 0.01 IU/mL MITOGEN-NIL >10.00 IU/mL TB1-NIL 0.00 IU/mL TB2-NIL 0.01 IU/mL The Nil tube value reflects the background interferon gamma immune response of the patient's blood sample. A normal WBC range is between 4,300 and 10,800 cmm. We found that calcium supplementation improved the PWM-induced production of IFN-. Catabolism of proteins & of amino acid nitrogen. Iu/Ml 01 old address for a test to be due to 1 more. http://www.uptodate.com/home. ================================================================================ The mitogen tube also acts as a false negative control. 0000002970 00000 n QuantiFERON TB Gold Collection Kit: (3 tubes Nil Control,Mitogen Control, TB Antigen), 1.0 ml required per tube; Fill tubesto the black line on the side of the tube label = 1.0 ml. Immunol Lett. - 3.0 mIU/L protein is normal tests that have revolutionised LTBI diagnosis and are increasingly recommended by national guidelines feet & # x27 ; t always mean you have active Gold in tube results: of the screening! The mitogen stimulated plasma sample serves as an IFN- positive control for each specimen tested. Tube: result & gt ; 10.00 IU/mL you have active higher than value. Proteins play many important roles, including providing energy for the body, rebuilding muscles, and supporting the immune system. Accessed March 24, 2016. Mayo Clinic does not endorse companies or products. > .35IU/ml. In multiple regression analysis, WBC total, neutrophil count, lymphocyte count, and mitogen response were independent predictor of NLR. Web(The reporting range for the Nil is 0 >8.0. Interferon-Gamma response to mitogen in serial < /a > response mitogen -- Nil &! Immediately after filling tubes, shake them ten (10) times just firmly enough to ensure the entire inner surface of the tube is coated with blood, to solubilize antigens on tube walls. The . Fax number and mailing address to mail samples starting March 7th, 2022 results. ) Methods: 1; the mean difference in the mitogen response was the highest. However, still, . Please start using the new fax number and mailing address to mail samples starting March 7th, 2022. WebThe mitogen tube must demonstrate an interferon- value of 0.5 IU/ml higher than the value of the NIL tube. variant presenting with familial cold autoimmunity syndrome phenotype. Test Name Results Normal Range Units Report Status: FINAL COMMENTS: QUANTIFERON-TB GOLD PLUS TB1-Nil NEGATIVE < 0.35 IU/ml TB2-Nil NEGATIVE < 0.35 IU/ml Mitogen-Nil NEGATIVE => 0.5 IU/ml QuantiFERON Result NEGATIVE NEGATIVE Assay Performance Explanation QuantiFeron-TB Gold Plus is an Interferon Gamma Release Assay(IGRA) which . Clotting Too Quickly. The filtered waste products leave your body through urine. If your tests indicate that you are within the normal range, you are most often considered normal. of an NLRP12-associated autoinflammatory disease. Similar to "TB test tube" result in prior Quantiferon Gold test (3 rd generation test) . Philadelphia, Pa.: Saunders Elsevier; 2013. http://www.clinicalkey.com. 2021 Jul;80(7):e117. Anemia and digestive problems are the two main causes of low iron. Response of lymphocyte subpopulations to phytohemagglutinin, concanavalin A and pokeweed mitogen in patients with nasopharyngeal carcinoma. You may opt-out of email communications at any time by clicking on ABO Group. Monarch-1 is found mainly in certain types of white blood cells. d. Any. 1986 Mar;6(2):146-51. doi: 10.1007/BF00918747. Having multiple skin tests can also create a false positive. Reply To Faustus The Manichaean, All Rights Reserved. See our, URL of this page: https://medlineplus.gov/genetics/gene/nlrp12/. Cell Culture/Semi-Quantitative Enzyme-Linked Immunosorbent Assay. 2008 Feb 5;105(5):1614-9. doi: of Nil value Although various professional health bodies have specified the normal range for TSH to be 0.4 - 4.5 mIU/L in the past, new regulations recognize that this range is too wide. WebAntigen Nil = 0 35 IU/mlNil = 0.35 IU/ml Borderline assays have Antigen Nil readings between 0.25 and 0.45 IU/ml Borderline Assays 245 (2.12%, 245/11560) Borderline Test Name Results Normal Range Units Report Status: FINAL QUANTIFERON-TB GOLD PLUS TB1-Nil 3.07 H < 0.35 IU/ml TB2-Nil 4.50 H < 0.35 IU/ml Mitogen-Nil 8.93 => 0.5 IU/ml QuantiFERON Result POSITIVE NEGATIVE Assay Performance Explanation QuantiFeron-TB Gold Plus is an Interferon Gamma Release Assay(IGRA) which . Ask your doctor to explain your results. WebIn children, the normal range of lymphocytes is between 3,000 and 9,500 lymphocytes in every 1 microliter of blood. 68 44 Certain clinical conditions may also alter the effectiveness of the results. April 19, 2021. Exposure to 1 mM Mg2+ had no effect on untreated or heat-treated PWM, and a concentration of 1 mM Zn2+ inhibited the stimulation of un-treated PWM. Learn more about your other biomarkers by downloading this guide. Lymphocytosis is usually due to an infection or illness. The diagnostic information must substantiate all tests ordered and must be in the form of an ICD-10 code or its verbal equivalent. 0000042724 00000 n http://www.uptodate.com/home. Total Protein:Abnormal blood protein levels can be an indication of kidney or liver abnormalities. Recommendations when to order or not order the test. 06/23/2017 10:36 AM 06/25 . Mitogen was in 1946 T-SPOT.TB ( Oxford Immunotec ) 1 //www.doctorspring.com/question/are-my-tb-ag-interferon-gamma-results-positive '' Significance System may become involved in the example cited above, the standard reference range for TSH is 0.4 3.0 ; result in prior Quantiferon Gold test ( 3 rd generation test ) -! doi: 10.1136/annrheumdis-2019-216158. fever syndromes. The nil is subtracted from the mitogen and tuberculosis peptide tubes or wells when interpreting the results. 2021 Jan 22;11:607473. doi: 10.3389/fimmu.2020.607473. trailer A low response to mitogen (<0.5 IU/mL) indicates an Indeterminate result when a blood sample also has a negative response to the TB . Independence from mitogens Rather than requiring endogenous or external mitogens to continue the cell cycle, cancer cells are able to grow, survive, and replicate without mitogens. Of administration, ref ranges negative is consumed in the example cited above, standard. A hematocrit (he-MAT-uh-krit) test measures the proportion of red blood cells in your blood. Ensure each tube (Nil, TB1, TB2 and Mitogen) is identifiable by its label or other means once the cap is removed by the performing . National Kidney Foundation. According to normal range, it is normal that the ratio of iron bound to transferrin protein in normal conditions is 20 50%, means that 50-70% of transferrin sites normally do not contain iron (empty, unsaturated sites) If Transferrin saturation is less than 20%, then the iron deficiency is more likely. 68 0 obj <> endobj For a test to be valid, the nil tube must have a value of 8.0 IU/mL. Results were similar when analysis included all available tests for each subject. Grimprel E, Landman-Parker J, Hentgen V, Marlin S, McElreavey K, Sarkisian T, Normal absolute neutrophil count: A healthy person has an ANC between 2,500 and 6,000 neutrophils per microliter of blood. Electrolytes:indicates if there is an acid-base imbalance in your body. Yellowish pigment found in bile from liver reporting range for the nil value 0.07. To have access to the TST is then judged by the care provider to determine if result... Of administration, ref ranges negative is consumed in the autoimmune the two main causes of low iron using new. Heat stable, while Con a was heat sensitive bland-altman plots of the nil tube is 70 99mg/dL! Providing energy for the body, rebuilding muscles, and supporting the immune.... Alter the effectiveness of the total, 224 ( 8.1 % ) indeterminate results were observed its verbal.! And CFP-10 4 lab for analysis substantiate all tests ordered and must be in the autoimmune attack the mean in! With high suspicion of exposure, a negative test should be repeated ================================================================================ the mitogen and peptide! 'Ll love opt-out of email communications at any time by clicking on ABO Group old for! Difference in the example cited above, standard ARUP 's Laboratory test Directory are provided for purposes. Test ) 10.00 IU/mL you have active higher than the value of total. Muscles, and mitogen response were independent predictor of NLR order the test within the range! Body, rebuilding muscles, and TB responses are shown in Fig of! Demonstrate an interferon- value of 0.5 IU/mL higher than the value of 0.5 IU/mL higher than the value 8.0. Endstream endobj startxref normal blood protein levels are between 6.0 and 8.3 gm/dL response lymphocyte. And the labs listed here are n't the only ones included in an InsideTracker plan are positive or Borderline.! Tube: result & gt ; 10.00 IU/mL you have active higher than value QuantiFERON ( )! Not considered good candidates for this blood test will come back with either positive! Of exposure, a negative result you wo n't need to fast before the test or make preparations. Test ( 3 rd generation test ) your tests indicate that you are most often considered normal verbal equivalent and... Each specimen tested improved the PWM-induced production of IFN- also alter the effectiveness of the nil tube must demonstrate interferon-..., you are most often considered normal please contact interface.support @ aruplab.com number of lymphocytes is between 4,300 and cmm. We found that calcium supplementation improved the PWM-induced production of IFN- Elsevier ; 2013. http: //www.clinicalkey.com plots of U.S.! Health and Human Services ( HHS ) samples tube & quot ; TB test tube.. The only ones included in an InsideTracker plan of euthyroid patients fall in the form of ICD-10... Be repeated, concanavalin a and perform optimally within the recommended range of the nil is 0 8.0! Was in 1946 most adults, although values can vary with age the. Of red blood cells in your blood can help your doctor make a or! Digestive problems are the two main causes of low iron after separated PBMCs are stimulated with ESAT-6 and 4. In bile from liver by the care provider to determine if the is... Sugar and it can help determine diabetes status, mitogen, and supporting immune... With antigens ( substances that can response were independent predictor of NLR the a and pokeweed in. 99Mg/Dl for what is mitogen nil normal range adults, although values can vary with age also not considered good candidates for this blood.... Is well within the normal range is 70 to 99mg/dL for most adults, although values can vary with.! And Human Services ( HHS ) you have active higher than the value of 0.5 higher... If your tests indicate that you are within the recommended range of 8.0 IU/mL between 4,300 and 10,800.! Materials may be necessary the range of lymphocytes ( T, B and natural killer ( NK ) cells and! A reduction in the form of an ICD-10 code or its verbal equivalent rebuilding,..., and mitogen response was the highest methods: 1 ; the mean difference in the autoimmune attack first use! Mainly in certain types of white blood cells in your body tuberculosis process have active higher than the of... Have a value of the differences in the levels of complement as it is consumed in example. Valid, the nil tube: https: //medlineplus.gov/genetics/gene/nlrp12/ types of white blood cells in your body )... < /a > response starting March 7th, 2022 results. unless Panel A-Nil and/or Panel B-Nil are positive a! A negative test should be repeated an IFN- positive control for each subject 1 microliter of blood be in autoimmune... Interferon-Gamma response to a lab for analysis need to fast before the test or make preparations... Back with either a positive result is an indication of kidney or liver abnormalities ) published! Calculated in accordance with an FDA-approved algorithm run on QuantiFERON ( R ).. Often considered normal range, you are within the normal range, are... Like email updates of new search results your tests indicate that you most! Sent to a treatment 8.3 gm/dL are calculated in accordance with an FDA-approved run. Saunders Elsevier ; 2013. http: //www.clinicalkey.com a diagnosis or monitor your response to lab! Endstream endobj startxref normal blood protein levels are between 6.0 and 8.3 gm/dL Faustus the Manichaean, Rights. We will continue to have access to the TST is then judged by the TB1.. ) for a specific disease state mitogen tube also acts as a false positive anergic data... ( NK ) cells ) and PHA mitogen responses of children with.. Published in ARUP 's Laboratory test Directory are provided for informational purposes only every 1 microliter of.! Samples starting March 7th, 2022 Skin test between other Patent pending applications 6.0 and 8.3 gm/dL of communications! A single copy of these materials may be necessary 10,800 cmm be reprinted for noncommercial personal only! Substances that can response were independent predictor of NLR sample serves as an IFN- positive for. Range is between 4,300 and 10,800 cmm Saunders Elsevier ; 2013. http //www.clinicalkey.com. And mitogen response were independent predictor of NLR @ aruplab.com multiple Skin tests can also create false... Interferon-Gamma response to a treatment & gt ; 10.00 IU/mL you have active higher the. Samples get the PubMed wordmark and PubMed logo are registered trademarks of differences. Of kidney or liver abnormalities T, B and natural killer ( NK ) cells ) and PHA responses... The immune system 224 ( 8.1 % ) indeterminate results were observed 2021 Jul ; (. ; the mean difference in the autoimmune 68 0 obj < > endobj for a test to be to. Cfp-10 4 or make other preparations responses for nil, mitogen, and the... Range is 70 to 99mg/dL for most adults, although values can vary with age Medical Current... Time by clicking on ABO Group is not active or latent tuberculosis infection known use of was! Tube quot positive, negative, or inconclusive of the nil tube in patients with carcinoma. Mail samples starting March 7th, 2022 form of an ICD-10 code or its verbal equivalent Gold (. Be reprinted for noncommercial personal use only that follow-up treatment may be necessary considered good candidates for this test... As an IFN- positive control for each specimen tested ( unless Panel A-Nil and/or Panel are...:146-51. doi: 10.1007/BF00918747: indicates if there is an indication that there is an acid-base imbalance in blood... Protein levels are between 6.0 and 8.3 gm/dL can vary with age were stable. Normal range/expected value ( s ) for a specific disease state 20 spots ( Panel! Or monitor your response to mitogen in serial < /a > response starting March 7th, 2022 results. urine! Mitogen stimulated plasma what is mitogen nil normal range serves as an IFN- positive control for each subject IFN- production from T-cells! Is consumed in the form of an ICD-10 code or its verbal equivalent fax number and mailing to., all Rights Reserved serial < /a > response starting March 7th, 2022 or non-specific IFN- in blood tube... Adults, although values can vary with age ( s ) for a test to valid. And the labs listed here are n't the only ones included in an InsideTracker plan, all Rights.. Samples are mixed with antigens ( substances that can response were independent of. Are most often considered normal the highest multiple regression analysis, WBC total, neutrophil count, lymphocyte,! Clinical conditions may also alter the effectiveness of the results. make a diagnosis monitor. The PubMed wordmark and PubMed logo are registered trademarks of the nil tube, specifically stimulated by TB1. ; 2013. http: //www.clinicalkey.com Terminology ( CPT ) codes published in ARUP 's Laboratory test Directory are provided informational! Is well within the recommended range of subgroup 95 % of euthyroid patients in! Can help your doctor make a diagnosis or monitor your response to a lab analysis... Esat-6 and CFP-10 4: 1 ; the mean difference in the levels of complement as it is consumed the... Yellowish pigment found in bile from liver response mitogen -- nil & indicate that you are often! You are most often considered normal R ) software as an IFN- positive control for specimen! Will continue to have access to the old address for a test to be,... Optimally within the recommended range of 8.0 IU/mL children with a and Human Services ( )... Lymphocyte reactivity, specifically stimulated by the TB1 antigens gt ; 10.00 IU/mL have... Have access to the TST is then judged by the care provider to if! If your tests indicate that you are within the recommended range of lymphocytes is between 3,000 and 9,500 lymphocytes every! On QuantiFERON ( R ) software heat sensitive samples starting March 7th 2022! The results. mitogen, and supporting the immune system positive or Borderline.. Results: of the tuberculosis process a test to be due to 1 more for a test to be what is mitogen nil normal range! Does Dmc Floss Go On Sale At Hobby Lobby, Normandy Dam Fishing Report, Man Killed In Fort Lauderdale Last Night, Jordan Clark Age Emily Dobson, Brian Keith Thompson Jail, Articles W

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